US researchers have discover chemical cocktails and opened a new battleground in the battle against ageing and diseases associated with old age through a ground-breaking study. In this research they have discover total six chemical cocktails to delay ageing process. The work, carried out by a group of researchers at MIT and Harvard Medical School, has published the first chemical method to reprogramme cells to a younger state.
This was previously only possible with a potent gene treatment. The research, which was published in the journal Aging-US, relies on the observation that adult cells can become induced pluripotent stem cells (iPSCs) by expressing particular genes known as Yamanaka factors. The 2012 Nobel Prize-winning finding raised the question of whether it could be able to stop biological ageing without making cells excessively young and susceptible to malignancy.
In the latest study, the researchers looked for chemicals that, when combined, could stop human cell ageing and rejuvenation. They created real-time nucleocytoplasmic protein compartmentalization (NCC) assays and transcription-based ageing clocks as high-throughput cell-based assays to distinguish between young and senescent cells.
In the fascinating finding, the team discovered six chemical cocktails that, in less than a week, reverse transcriptome ageing and return NCC and genome-wide transcript profiles to youthful levels. “Up until recently, gradual ageing was the most we could manage. According to the primary researcher, Professor David A. Sinclair of Harvard’s Department of Genetics, “new findings imply we can now reverse it.
The widespread adoption of this procedure was previously constrained by the need for gene therapy, he continued. By virally introducing particular Yamanaka genes into cells, the Harvard researchers previously showed that it is possible to reverse cellular ageing without unchecked cell proliferation.
Promising findings have been found in research on the optic nerve, brain tissue, kidney, and muscle. enhanced vision and an extended lifespan have been seen in mice, and more recently, enhanced vision in monkeys has been reported.
Discovery Of Six Chemical Cocktails
This new discovery of new six chemical cocktails, has far-reaching consequences, potentially leading to whole-body regeneration and regenerative medicine. This breakthrough could transform the treatment of ageing, accidents, and age-related disorders by creating a chemical substitute for age reversal via gene therapy. It also provides the possibility of reduced prices and quicker development times.
The lab’s age reversal gene therapy is currently undergoing preparations for human clinical trials in the wake of successful results in reversing blindness in monkeys in April 2023. In the future, according to the Harvard researchers, age-related illnesses will be successfully treated, injuries will be cured more quickly, and the possibility of whole-body regeneration will become a reality.
With implications ranging from bettering eyesight to effectively curing many age-related ailments, this new finding “offers the potential to reverse ageing with a single pill,” Sinclair said.
