According to a peer-reviewed analysis of phase 2 clinical trial data released Monday, an oral medication produced by Pfizer medicine induces a comparable level of weight reduction as rival Novo Nordisk’s popular injection Ozempic.
Late last year, the findings were presented at a medical conference; no comparisons were made between Ozempic or other weight-loss drugs and Pfizer medicine. It took JAMA Network some time to publish a peer-reviewed study.
The Pfizer Experiment
In a Pfizer medicine experiment, 411 persons with Type 2 diabetes were given either a placebo or the company’s medication, danuglipron, twice daily. The study discovered that after patients took either the 120-milligram or 80-milligram forms of danuglipron for 16 weeks, their body weight was “statistically significantly reduced.” Over that time, patients who took a 120-milligram version dropped, on average, about 10 pounds.
As an alternative to regular injections, Pfizer medicine may have a benefit. Although there are significant disparities in dose levels, the study’s findings also imply that danuglipron may be just as beneficial for weight loss as Ozempic. According to a phase 3 clinical trial on Ozempic, adults who received a 1-milligram dose of the injection lost an average of 9.9 pounds over the course of 30 weeks. Once per week, patients receive that shot.
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Drug usage for Diabetes
In the US, Ozempic is approved to treat diabetes, but it’s also being taken off-label to help people lose weight. Wegovy, a similar medication made by Novo Nordisk, is licensed for “chronic weight management.” In a Wegovy phase 3 clinical trial, adults who received a weekly injection of 2.4 milligrams on average lost 33 pounds over 68 weeks.
Drugs of the glucagon-like peptide-1 agonist class include Danuglipron, Ozempic, and Wegovy. They imitate the GLP-1 hormone, which alerts the brain when a person is full and is generated in the gut. The medications can also aid in the management of Type 2 diabetes because they promote the production of insulin from the pancreas, which lowers blood sugar levels.